Which syndrome manifests with no lactation postpartum, absent menstruation, and cold intolerance?

Which syndrome manifests with no lactation postpartum, absent menstruation, and cold intolerance?

• A. Sheehan's syndrome
• B. Turner syndrome
• C. Asherman's syndrome
• D. Polycystic ovary syndrome

Answer: (A)

Sheehan's syndrome is characterized by failure of the pituitary gland to function properly after significant blood loss during or after childbirth. This leads to pituitary insufficiency, which can manifest in several hormonal deficiencies. The symptoms you describe—absence of lactation (agalactia), absent menstruation (amenorrhea), and cold intolerance—are closely related to the endocrine disruptions seen in this condition. In Sheehan's syndrome, the lack of prolactin due to pituitary failure results in the inability to lactate. The absence of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) contributes to amenorrhea. Additionally, decreased levels of thyroid-stimulating hormone (TSH) can lead to hypothyroidism, which is associated with symptoms such as cold intolerance. Collectively, these hormonal deficiencies create the clinical picture observed in Sheehan's syndrome. The other syndromes listed have different pathophysiological mechanisms and clinical manifestations unrelated to the combination of symptoms provided in the question. Thus, Sheehan's syndrome stands out for its specific association with postpartum pituitary failure and the resulting symptoms.

Sheehan's syndrome is characterized by failure of the pituitary gland to function properly after significant blood loss during or after childbirth. This leads to pituitary insufficiency, which can manifest in several hormonal deficiencies. The symptoms you describe—absence of lactation (agalactia), absent menstruation (amenorrhea), and cold intolerance—are closely related to the endocrine disruptions seen in this condition.

In Sheehan's syndrome, the lack of prolactin due to pituitary failure results in the inability to lactate. The absence of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) contributes to amenorrhea. Additionally, decreased levels of thyroid-stimulating hormone (TSH) can lead to hypothyroidism, which is associated with symptoms such as cold intolerance. Collectively, these hormonal deficiencies create the clinical picture observed in Sheehan's syndrome.

The other syndromes listed have different pathophysiological mechanisms and clinical manifestations unrelated to the combination of symptoms provided in the question. Thus, Sheehan's syndrome stands out for its specific association with postpartum pituitary failure and the resulting symptoms.