Which genetic marker is associated with Hashimoto's thyroiditis?

Which genetic marker is associated with Hashimoto's thyroiditis?

• A. HLA-B27
• B. HLA-DR5
• C. HLA-DQ2
• D. HLA-A1

Answer: (B)

Hashimoto's thyroiditis is an autoimmune condition characterized by the destruction of thyroid tissue, often leading to hypothyroidism. The genetic marker most commonly associated with this disease is HLA-DR5. The HLA (human leukocyte antigen) system is crucial in the immune system's ability to distinguish between self and non-self. Specific HLA class II alleles, such as HLA-DR5, have been identified as having a strong association with Hashimoto's thyroiditis. This association suggests that individuals carrying this particular allele may have an increased susceptibility to develop this autoimmune disorder. In contrast, other HLA types listed do not have the same level of connection with Hashimoto's thyroiditis. Therefore, HLA-DR5 stands out as the correct genetic marker linked to this condition, helping to emphasize the importance of genetic predisposition in autoimmune diseases.

Hashimoto's thyroiditis is an autoimmune condition characterized by the destruction of thyroid tissue, often leading to hypothyroidism. The genetic marker most commonly associated with this disease is HLA-DR5.

The HLA (human leukocyte antigen) system is crucial in the immune system's ability to distinguish between self and non-self. Specific HLA class II alleles, such as HLA-DR5, have been identified as having a strong association with Hashimoto's thyroiditis. This association suggests that individuals carrying this particular allele may have an increased susceptibility to develop this autoimmune disorder.

In contrast, other HLA types listed do not have the same level of connection with Hashimoto's thyroiditis. Therefore, HLA-DR5 stands out as the correct genetic marker linked to this condition, helping to emphasize the importance of genetic predisposition in autoimmune diseases.