Which enzyme is inhibited by Zileuton?

Which enzyme is inhibited by Zileuton?

• A. Phospholipase A2
• B. Cyclooxygenase
• C. Leukotriene synthase
• D. Lipoxygenase

Answer: (D)

Zileuton is a medication specifically used to manage asthma by inhibiting the synthesis of leukotrienes, which are inflammatory mediators involved in the pathophysiology of asthma and other allergic conditions. The primary enzyme that Zileuton inhibits is lipoxygenase. Lipoxygenase is crucial in the biosynthesis of leukotrienes from arachidonic acid, and by inhibiting this enzyme, Zileuton decreases the formation of leukotrienes, thereby reducing airway inflammation and bronchoconstriction associated with asthma. Understanding the specific target of Zileuton helps in appreciating how it fits into the broader category of asthma management strategies, which may include other classes of drugs that target different pathways, such as glucocorticoids or bronchodilators.

Zileuton is a medication specifically used to manage asthma by inhibiting the synthesis of leukotrienes, which are inflammatory mediators involved in the pathophysiology of asthma and other allergic conditions. The primary enzyme that Zileuton inhibits is lipoxygenase. Lipoxygenase is crucial in the biosynthesis of leukotrienes from arachidonic acid, and by inhibiting this enzyme, Zileuton decreases the formation of leukotrienes, thereby reducing airway inflammation and bronchoconstriction associated with asthma.

Understanding the specific target of Zileuton helps in appreciating how it fits into the broader category of asthma management strategies, which may include other classes of drugs that target different pathways, such as glucocorticoids or bronchodilators.